Tomatidine CAS 6192-62-7

Tomatidine is a steroidal alkaloid found in the skins of unripe tomatoes. An LPS-stimulated macrophage model of inflammation was used to investigate the anti-inflammatory effects of tomatidine and it was found that the alkaloid could decrease inducible nitric oxide synthase and cyclooxygenase-2 expression through suppression of I-kappa B alpha phosphorylation.

Thus it may be possible that Tomatidine can be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases. When incorporated into growth media (agar) at 0.3 mM, tomatine and tomatidine inhibited the growth of three fungal bioherbicidal phytopathogens.

Alternaria cassiae (weed host = sicklepod), the most sensitive pathogen was inhibited 70% by both compounds. Tomatine inhibited Colletotrichum truncatum (weed host = hemp sesbania) and Fusarium subglutinans (produces fumonisin, phytotoxic to many plants) growth by 63% and 50%, respectively; while tomatidine inhibited the growth of these latter two pathogens by 50% and 15%, respectively.

These natural plant products were shown to have a broad range phytotoxicity and fungitoxicity which may be important in plant defense mechanisms.

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